The most effective use of immunoassay methods
is to make rapid screening decisions before samples are
analyzed by slower and more expensive methods. The CAPE
Technologies High Performance Dioxin/Furan Immunoassay
Kit is designed to screen samples at selected PCDD/F levels.
In a properly designed screening program, this Enzyme Immunoassay
(EIA) supplements conventional methods, but does not replace
them.
In summary, all samples from a project are
screened using the immunoassay method. All samples which
are positive at the decision level are then analyzed by
the standard method. Some randomly selected fraction (typically
5 to 20%) of negative samples are also analyzed by the standard
method. Thus, most EIA negative samples are never analyzed
by the conventional method.
Project cost models provided by CAPE
Technologies are based on this approach. This
approach has been embodied in the successful US EPA 4000
series of immunoassay screening methods (PCB, PAH, etc.).
A more complete description of this screening approach and
its application to dioxin analysis is being developed.
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